Prof. Kiyonao Sada M.D., Ph.D.

Name:

Kiyonao SADA

Title:

Professor

Date of birth:

April 16, 1966

Field:

Molecular Biology, Virology, Immunology

Membership:

Japanese Biochemical Society, Japanese Society for Virology, American Association of Immunologists

Interests:

DTM

Research Outline:

Molecular scaffold, adaptor proteins have indispensable roles to switch the receptor-activating signals to the downstream effectors by assembling, targeting and regulating the signaling molecules. Several adaptor proteins are the substrate of proximal protein-tyrosine kinases. These molecules lack the catalytic activity, but they have multiple motifs and domains that allow binding to the other signaling molecules and therefore act as positive or negative regulators controlling the intracellular signal transduction. We are currently working on the signal transduction mediated by the adaptor protein 3BP2 (c-Abl Src homology 3 domain-binding protein-2, also referred to SH3BP2) to reveal its physiopathological role in lymphocytes and myeloid-lineage cells, by utilizing the techniques combine the various mutant cDNA transfection, RNA interference, and genetic analysis of the signaling molecules.

Message:

We welcome you who are interested in life science, and who wish to clarify mysterious life phenomenon in a substantial level, especially by the analysis of signal transduction. For further information, please refer to our recent publications listed in our web page.